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==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with Junctional Adhesion Molecule-A==
==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with Junctional Adhesion Molecule-A==
<StructureSection load='4odb' size='340' side='right' caption='[[4odb]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4odb' size='340' side='right'caption='[[4odb]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4odb]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mrv-1 Mrv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ODB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4odb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ODB FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gu3|4gu3]], [[4gu4|4gu4]], [[3eoy|3eoy]], [[1nbq|1nbq]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odb OCA], [https://pdbe.org/4odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4odb RCSB], [https://www.ebi.ac.uk/pdbsum/4odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4odb ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10884 MRV-1]), F11R, JAM1, JCAM, UNQ264/PRO301 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4odb OCA], [http://pdbe.org/4odb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4odb RCSB], [http://www.ebi.ac.uk/pdbsum/4odb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4odb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). [[http://www.uniprot.org/uniprot/JAM1_HUMAN JAM1_HUMAN]] Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
[https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
 
==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Mrv-1]]
[[Category: Large Structures]]
[[Category: Stehle, T]]
[[Category: Mammalian orthoreovirus 1 Lang]]
[[Category: Stettner, E]]
[[Category: Stehle T]]
[[Category: Beta spiral]]
[[Category: Stettner E]]
[[Category: Capsid protein]]
[[Category: Cell adhesion molecule]]
[[Category: Greek key motif]]
[[Category: Immunoglobulin fold]]
[[Category: Viral attachment protein]]
[[Category: Viral protein]]
[[Category: Viral receptor]]
Retrieved from "https://proteopedia.org/4odb"