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==Crystal Structure of Alg17c Mutant Y258A Complexed with Alginate Trisaccharide==
==Crystal Structure of Alg17c Mutant Y258A Complexed with Alginate Trisaccharide==
<StructureSection load='4ojz' size='340' side='right' caption='[[4ojz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4ojz' size='340' side='right'caption='[[4ojz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ojz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Microbulbifer_degradans_2-40 Microbulbifer degradans 2-40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OJZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ojz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharophagus_degradans_2-40 Saccharophagus degradans 2-40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OJZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=BEM:BETA-D-MANNURONIC+ACID'>BEM</scene>, <scene name='pdbligand=LGU:ALPHA-L-GULURONATE'>LGU</scene>, <scene name='pdbligand=MAV:ALPHA-D-MANNOPYRANURONIC+ACID'>MAV</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEM:BETA-D-MANNURONIC+ACID'>BEM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LGU:ALPHA-L-GULURONATE'>LGU</scene>, <scene name='pdbligand=MAV:ALPHA-D-MANNOPYRANURONIC+ACID'>MAV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ok2|4ok2]], [[4ok4|4ok4]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ojz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ojz OCA], [https://pdbe.org/4ojz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ojz RCSB], [https://www.ebi.ac.uk/pdbsum/4ojz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ojz ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alg17A, alg17C, Sde_3284 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=203122 Microbulbifer degradans 2-40])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ojz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ojz OCA], [http://pdbe.org/4ojz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ojz RCSB], [http://www.ebi.ac.uk/pdbsum/4ojz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ojz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EALGL_SACD2 EALGL_SACD2] Catalyzes the depolymerization of alginate through an exolytic mode of action, via a beta-elimination mechanism. Preferentially acts on oligoalginates with degrees of polymerization higher than 2 to produce the alginate monomer, 4-deoxy-L-erythro-5-hexoseulose uronic acid.<ref>PMID:22281843</ref> <ref>PMID:24478312</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Microbulbifer degradans 2-40]]
[[Category: Large Structures]]
[[Category: Nair, S K]]
[[Category: Saccharophagus degradans 2-40]]
[[Category: Park, D S]]
[[Category: Nair SK]]
[[Category: Alginate lyase]]
[[Category: Park DS]]
[[Category: Lyase]]
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