4om2: Difference between revisions

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==Crystal structure of TLE1 N-terminal Q-domain residues 1-156==
==Crystal structure of TLE1 N-terminal Q-domain residues 1-156==
<StructureSection load='4om2' size='340' side='right' caption='[[4om2]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
<StructureSection load='4om2' size='340' side='right'caption='[[4om2]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4om2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OM2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4om2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OM2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4om3|4om3]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4om2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om2 OCA], [https://pdbe.org/4om2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4om2 RCSB], [https://www.ebi.ac.uk/pdbsum/4om2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4om2 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLE, TLE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om2 OCA], [http://pdbe.org/4om2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4om2 RCSB], [http://www.ebi.ac.uk/pdbsum/4om2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4om2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN]] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>
[https://www.uniprot.org/uniprot/TLE1_HUMAN TLE1_HUMAN] Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.<ref>PMID:10660609</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chodaparambil, J V]]
[[Category: Large Structures]]
[[Category: Weis, W I]]
[[Category: Chodaparambil JV]]
[[Category: Dna binding]]
[[Category: Weis WI]]
[[Category: Helix-turn-helix]]
[[Category: Tcf/lef]]
[[Category: Tetramer]]
[[Category: Transcription]]
[[Category: Wnt repressor]]
Retrieved from "https://proteopedia.org/4om2"