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==Crystal structure of TIR domain of TLR6==
==Crystal structure of TIR domain of TLR6==
<StructureSection load='4om7' size='340' side='right' caption='[[4om7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4om7' size='340' side='right'caption='[[4om7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4om7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OM7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4om7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OM7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLR6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4om7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om7 OCA], [https://pdbe.org/4om7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4om7 RCSB], [https://www.ebi.ac.uk/pdbsum/4om7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4om7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om7 OCA], [http://pdbe.org/4om7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4om7 RCSB], [http://www.ebi.ac.uk/pdbsum/4om7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4om7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TLR6_HUMAN TLR6_HUMAN]] Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.<ref>PMID:11441107</ref>
[https://www.uniprot.org/uniprot/TLR6_HUMAN TLR6_HUMAN] Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.<ref>PMID:11441107</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4om7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4om7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Jang, T H]]
[[Category: Large Structures]]
[[Category: Park, H H]]
[[Category: Jang TH]]
[[Category: Protein interaction]]
[[Category: Park HH]]
[[Category: Signaling protein]]
[[Category: Tir fold]]
Retrieved from "https://proteopedia.org/4om7"