4oo7: Difference between revisions

<table><tr><td colspan='2'>[[4oo7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OO7 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo7 OCA], [https://pdbe.org/4oo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oo7 RCSB], [https://www.ebi.ac.uk/pdbsum/4oo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo7 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CISD2_HUMAN CISD2_HUMAN] Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2) [MIM:[https://omim.org/entry/604928 604928]. A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent.<ref>PMID:17846994</ref>  

[https://www.uniprot.org/uniprot/CISD2_HUMAN CISD2_HUMAN] Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.<ref>PMID:17846994</ref> <ref>PMID:20010695</ref>  

[[Category: Homo sapiens]]

[[Category: Colman AR]]

[[Category: Eisenberg-Domovich Y]]

[[Category: Jenning PA]]

[[Category: Lipper CH]]

[[Category: Livnah O]]

[[Category: Nechushtai R]]

[[Category: Paddock ML]]

[[Category: Stofleth JT]]

[[Category: Tamir S]]