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==Crystal structure of biotin protein ligase (RV3279C) of Mycobacterium tuberculosis, complexed with biotinyl-5'-AMP==
==Crystal structure of biotin protein ligase (RV3279C) of Mycobacterium tuberculosis, complexed with biotinyl-5'-AMP==
<StructureSection load='4op0' size='340' side='right' caption='[[4op0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4op0' size='340' side='right'caption='[[4op0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4op0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OP0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OP0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4op0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OP0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BT5:BIOTINYL-5-AMP'>BT5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BT5:BIOTINYL-5-AMP'>BT5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">birA, MT3379, Rv3279c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4op0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4op0 OCA], [https://pdbe.org/4op0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4op0 RCSB], [https://www.ebi.ac.uk/pdbsum/4op0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4op0 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Biotin--[acetyl-CoA-carboxylase]_ligase Biotin--[acetyl-CoA-carboxylase] ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.15 6.3.4.15] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4op0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4op0 OCA], [http://pdbe.org/4op0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4op0 RCSB], [http://www.ebi.ac.uk/pdbsum/4op0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4op0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BIRA_MYCTU BIRA_MYCTU] Catalyzes the transfer of biotin onto a conserved lysine residue of the biotin carboxyl carrier protein (BCCP) domain of acetyl-CoA carboxylase and converts it to active holo-BCCP (PubMed:18509457, PubMed:24723382). Forms an acyl-adenylate intermediate (PubMed:18509457, PubMed:24723382). Cannot use GTP or desthiobiotin (PubMed:18509457).<ref>PMID:18509457</ref> <ref>PMID:24723382</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4op0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4op0" style="background-color:#fffaf0;"></div>
==See Also==
*[[Biotin Protein Ligase|Biotin Protein Ligase]]
*[[Biotin Protein Ligase 3D structures|Biotin Protein Ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Akhter, Y]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Ma, Q]]
[[Category: Akhter Y]]
[[Category: Wilmanns, M]]
[[Category: Ma Q]]
[[Category: Bira]]
[[Category: Wilmanns M]]
[[Category: Ligase]]
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