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==Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe==
==Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe==
<StructureSection load='4oqe' size='340' side='right' caption='[[4oqe]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4oqe' size='340' side='right'caption='[[4oqe]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4oqe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_fradii"_(sic)_waksman_and_curtis_1916 "actinomyces fradii" (sic) waksman and curtis 1916]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4oqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMF:DTDP-3-N-METHYLAMINO-3,6-DIDEOXYGALACTOSE'>MMF</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMF:DTDP-3-N-METHYLAMINO-3,6-DIDEOXYGALACTOSE'>MMF</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oqd|4oqd]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqe OCA], [https://pdbe.org/4oqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oqe RCSB], [https://www.ebi.ac.uk/pdbsum/4oqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqe ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tylM1, tylMI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1906 "Actinomyces fradii" (sic) Waksman and Curtis 1916])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose_N,N-dimethyltransferase dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.235 2.1.1.235] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oqe OCA], [http://pdbe.org/4oqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oqe RCSB], [http://www.ebi.ac.uk/pdbsum/4oqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oqe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYLM1_STRFR TYLM1_STRFR]] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>
[https://www.uniprot.org/uniprot/TYLM1_STRFR TYLM1_STRFR] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase]]
[[Category: Large Structures]]
[[Category: Holden, H M]]
[[Category: Streptomyces fradiae]]
[[Category: Thoden, J B]]
[[Category: Holden HM]]
[[Category: N-methyltransferase]]
[[Category: Thoden JB]]
[[Category: S-adenosylmethionine]]
[[Category: Sam methyltransferase]]
[[Category: Transferase]]

Revision as of 07:39, 25 January 2023

Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Fuc3NMe

4oqe, resolution 2.20Å

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