7wrn: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7wrn is ~~ON HOLD until Paper Publication~~

==ESRP1 RNaseH-qRRM1 tandem domain==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7wrn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRN FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wrn OCA], [https://pdbe.org/7wrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wrn RCSB], [https://www.ebi.ac.uk/pdbsum/7wrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wrn ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ESRP1_HUMAN ESRP1_HUMAN] mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Guo WT]]

[[Category: Patel DJ]]

[[Category: Wu BX]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7wrn is ON HOLD  until Paper Publication
+==ESRP1 RNaseH-qRRM1 tandem domain==
+<StructureSection load='7wrn' size='340' side='right'caption='[[7wrn]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7wrn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRN FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wrn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wrn OCA], [https://pdbe.org/7wrn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wrn RCSB], [https://www.ebi.ac.uk/pdbsum/7wrn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wrn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ESRP1_HUMAN ESRP1_HUMAN] mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Guo WT]]
+[[Category: Patel DJ]]
+[[Category: Wu BX]]