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==Crystal structure of a G-rich RNA sequence binding factor 1 (GRSF1) from Homo sapiens at 1.75 A resolution==
==Crystal structure of a G-rich RNA sequence binding factor 1 (GRSF1) from Homo sapiens at 1.75 A resolution==
<StructureSection load='4qu6' size='340' side='right' caption='[[4qu6]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='4qu6' size='340' side='right'caption='[[4qu6]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qu6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QU6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QU6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qu6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QU6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BC040485, GRSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qu6 OCA], [https://pdbe.org/4qu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qu6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qu6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qu6 OCA], [http://pdbe.org/4qu6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qu6 RCSB], [http://www.ebi.ac.uk/pdbsum/4qu6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qu6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GRSF1_HUMAN GRSF1_HUMAN]] Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.<ref>PMID:23473033</ref> <ref>PMID:23473034</ref>
[https://www.uniprot.org/uniprot/GRSF1_HUMAN GRSF1_HUMAN] Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences.<ref>PMID:23473033</ref> <ref>PMID:23473034</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Structural genomic]]
[[Category: Large Structures]]
[[Category: TCELL, Partnership for T-Cell Biology]]
[[Category: Synthetic construct]]
[[Category: Jcsg]]
[[Category: Partnership for t-cell biology]]
[[Category: Pf14259 family]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Rna binding domain]]
[[Category: Rna binding protein-rna complex]]
[[Category: Rna-binding protein]]
[[Category: Rrm_6]]
[[Category: Tcell]]
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