4p2a: Difference between revisions

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<StructureSection load='4p2a' size='340' side='right'caption='[[4p2a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4p2a' size='340' side='right'caption='[[4p2a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p2a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2A FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P2A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fau|2fau]], [[3qdo|3qdo]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2a OCA], [https://pdbe.org/4p2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p2a RCSB], [https://www.ebi.ac.uk/pdbsum/4p2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2a ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vps26a, Vps26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Snx27, Mrt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2a OCA], [http://pdbe.org/4p2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p2a RCSB], [http://www.ebi.ac.uk/pdbsum/4p2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VP26A_MOUSE VP26A_MOUSE]] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). [[http://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT]] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).  
[https://www.uniprot.org/uniprot/VP26A_MOUSE VP26A_MOUSE] Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Sorting nexin|Sorting nexin]]
*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
*[[Vacuolar protein sorting-associated protein|Vacuolar protein sorting-associated protein]]
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Clairfeuille, T]]
[[Category: Rattus norvegicus]]
[[Category: Collins, B]]
[[Category: Clairfeuille T]]
[[Category: Cullen, P]]
[[Category: Collins B]]
[[Category: Gallon, M]]
[[Category: Cullen P]]
[[Category: Ghai, R]]
[[Category: Gallon M]]
[[Category: Mas, C]]
[[Category: Ghai R]]
[[Category: Teasdale, R]]
[[Category: Mas C]]
[[Category: Retromer]]
[[Category: Teasdale R]]
[[Category: Sorting nexin]]
[[Category: Transport protein]]
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