7s1f: Difference between revisions

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'''Unreleased structure'''


The entry 7s1f is ON HOLD  until Paper Publication
==Crystal structure of E.coli DsbA in complex with compound MIPS-0001886 (compound 38)==
 
<StructureSection load='7s1f' size='340' side='right'caption='[[7s1f]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
Authors: Heras, B., Scanlon, M.J., Martin, J.L., Caria, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7s1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S1F FirstGlance]. <br>
Description: Crystal structure of E.coli DsbA in complex with compound MIPS-0001886 (compound 38)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VB:1-[(3-thiophen-3-ylphenyl)methyl]-3~{H}-pyrrol-2-one'>5VB</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s1f OCA], [https://pdbe.org/7s1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s1f RCSB], [https://www.ebi.ac.uk/pdbsum/7s1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s1f ProSAT]</span></td></tr>
[[Category: Martin, J.L]]
</table>
[[Category: Scanlon, M.J]]
== Function ==
[[Category: Heras, B]]
[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>
[[Category: Caria, S]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Caria S]]
[[Category: Heras B]]
[[Category: Martin JL]]
[[Category: Scanlon MJ]]
Retrieved from "https://proteopedia.org/7s1f"