7y0d: Difference between revisions
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==Cryo-EM structure of the Mycobacterium smegmatis DNA integrity scanning protein (MsDisA).== | |||
<StructureSection load='7y0d' size='340' side='right'caption='[[7y0d]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y0d]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y0D FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y0d OCA], [https://pdbe.org/7y0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y0d RCSB], [https://www.ebi.ac.uk/pdbsum/7y0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y0d ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Chatterji | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/DISA_MYCS2 DISA_MYCS2] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.[HAMAP-Rule:MF_01438] Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.[HAMAP-Rule:MF_01438]<ref>PMID:23760274</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycolicibacterium smegmatis MC2 155]] | |||
[[Category: Chatterji D]] | |||
[[Category: Gautam S]] | |||
[[Category: Vinothkumar KR]] | |||
Revision as of 06:43, 8 February 2023
Cryo-EM structure of the Mycobacterium smegmatis DNA integrity scanning protein (MsDisA).
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