4pni: Difference between revisions
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<StructureSection load='4pni' size='340' side='right'caption='[[4pni]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='4pni' size='340' side='right'caption='[[4pni]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pni]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4pni]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNI FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KQQ:3-[(2-{[1-(N,N-DIMETHYLGLYCYL)-6-METHOXY-4,4-DIMETHYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]AMINO}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]THIOPHENE-2-CARBOXAMIDE'>KQQ</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KQQ:3-[(2-{[1-(N,N-DIMETHYLGLYCYL)-6-METHOXY-4,4-DIMETHYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]AMINO}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]THIOPHENE-2-CARBOXAMIDE'>KQQ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pni OCA], [https://pdbe.org/4pni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pni RCSB], [https://www.ebi.ac.uk/pdbsum/4pni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pni ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GRK1_BOVIN GRK1_BOVIN] Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).[UniProtKB:Q9WVL4]<ref>PMID:12686556</ref> <ref>PMID:16675451</ref> <ref>PMID:21299498</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[Regulator of G protein signaling|Regulator of G protein signaling]] | *[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]] | ||
*[[Rhodopsin kinase|Rhodopsin kinase]] | *[[Rhodopsin kinase|Rhodopsin kinase]] | ||
== References == | == References == | ||
| Line 29: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Homan KT]] | |||
[[Category: Homan | [[Category: Tesmer JJG]] | ||
[[Category: Tesmer | |||
