4q0o: Difference between revisions

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<StructureSection load='4q0o' size='340' side='right'caption='[[4q0o]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='4q0o' size='340' side='right'caption='[[4q0o]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q0O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XC:(2E)-1-(2-HYDROXYPHENYL)-3-[(3R)-3-PHENYLPIPERIDIN-1-YL]PROP-2-EN-1-ONE'>2XC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0n|4q0n]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [https://pdbe.org/4q0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [https://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAF180, PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0o OCA], [http://pdbe.org/4q0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q0o RCSB], [http://www.ebi.ac.uk/pdbsum/4q0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q0o ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Filippakopoulos P]]
[[Category: Filippakopoulos, P]]
[[Category: Knapp S]]
[[Category: Knapp, S]]
[[Category: Picaud S]]
[[Category: Picaud, S]]
[[Category: Von Delft F]]
[[Category: Structural genomic]]
[[Category: Baf180]]
[[Category: Brg1-associated factor 180]]
[[Category: Bromodomain]]
[[Category: Chromatin regulator]]
[[Category: Dna-binding]]
[[Category: Nucleus]]
[[Category: Pb1]]
[[Category: Pbrm1]]
[[Category: Polybromo 1 isoform 1]]
[[Category: Polybromo-1d]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
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