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==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and A110==
==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and A110==
<StructureSection load='4q33' size='340' side='right' caption='[[4q33]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
<StructureSection load='4q33' size='340' side='right'caption='[[4q33]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q33]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Clop1 Clop1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q33 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q33]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_ATCC_13124 Clostridium perfringens ATCC 13124]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q33 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2YA:4-[(1R)-1-[1-(4-CHLOROPHENYL)-1,2,3-TRIAZOL-4-YL]ETHOXY]-1-OXIDANYL-QUINOLINE'>2YA</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2YA:4-[(1R)-1-[1-(4-CHLOROPHENYL)-1,2,3-TRIAZOL-4-YL]ETHOXY]-1-OXIDANYL-QUINOLINE'>2YA</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q32|4q32]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q33 OCA], [https://pdbe.org/4q33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q33 RCSB], [https://www.ebi.ac.uk/pdbsum/4q33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q33 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPF_2558, guaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195103 CLOP1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q33 OCA], [http://pdbe.org/4q33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q33 RCSB], [http://www.ebi.ac.uk/pdbsum/4q33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q33 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q0TN42_CLOP1 Q0TN42_CLOP1]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964]  
[https://www.uniprot.org/uniprot/A0A0H2YRZ7_CLOP1 A0A0H2YRZ7_CLOP1] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
 
==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clop1]]
[[Category: Clostridium perfringens ATCC 13124]]
[[Category: IMP dehydrogenase]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Anderson WF]]
[[Category: Structural genomic]]
[[Category: Gollapalli DR]]
[[Category: Gollapalli, D R]]
[[Category: Gorla SK]]
[[Category: Gorla, S K]]
[[Category: Gu M]]
[[Category: Gu, M]]
[[Category: Hedstrom L]]
[[Category: Hedstrom, L]]
[[Category: Joachimiak A]]
[[Category: Joachimiak, A]]
[[Category: Kim Y]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska M]]
[[Category: Makowska-Grzyska, M]]
[[Category: Maltseva N]]
[[Category: Maltseva, N]]
[[Category: Mandapati K]]
[[Category: Mandapati, K]]
[[Category: Mulligan R]]
[[Category: Mulligan, R]]
[[Category: Zhang M]]
[[Category: Zhang, M]]
[[Category: Csgid]]
[[Category: Dehydrogenase]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Oxidoreductase]]
[[Category: Tim barrel]]

Revision as of 07:41, 8 February 2023

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and A110

4q33, resolution 2.88Å

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