4q4n: Difference between revisions

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<StructureSection load='4q4n' size='340' side='right'caption='[[4q4n]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
<StructureSection load='4q4n' size='340' side='right'caption='[[4q4n]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4q4n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q4N FirstGlance]. <br>
<table><tr><td colspan='2'>[[4q4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q4N FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q4g|4q4g]], [[4q4t|4q4t]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4n OCA], [https://pdbe.org/4q4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q4n RCSB], [https://www.ebi.ac.uk/pdbsum/4q4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4n ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ripA, Rv1477 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q4n OCA], [http://pdbe.org/4q4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q4n RCSB], [http://www.ebi.ac.uk/pdbsum/4q4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q4n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIPA_MYCTU RIPA_MYCTU]] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref>
[https://www.uniprot.org/uniprot/RIPA_MYCTU RIPA_MYCTU] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Berisio, R]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Romano, M]]
[[Category: Berisio R]]
[[Category: Ruggiero, A]]
[[Category: Romano M]]
[[Category: Squeglia, F]]
[[Category: Ruggiero A]]
[[Category: Vitagliano, L]]
[[Category: Squeglia F]]
[[Category: Alpha-beta]]
[[Category: Vitagliano L]]
[[Category: Hydrolase]]
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