5om9: Difference between revisions
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==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor== | ==Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor== | ||
<StructureSection load='5om9' size='340' side='right' caption='[[5om9]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='5om9' size='340' side='right'caption='[[5om9]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5om9]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5om9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uf4 4uf4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OM9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O2S:(2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic+acid'>O2S</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O2S:(2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic+acid'>O2S</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5om9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5om9 OCA], [https://pdbe.org/5om9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5om9 RCSB], [https://www.ebi.ac.uk/pdbsum/5om9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5om9 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5om9" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5om9" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Aviles | [[Category: Aviles FX]] | ||
[[Category: Covaleda | [[Category: Covaleda G]] | ||
[[Category: Fernandez | [[Category: Fernandez D]] | ||
[[Category: Gallego | [[Category: Gallego P]] | ||
[[Category: Granados | [[Category: Granados C]] | ||
[[Category: Pallares | [[Category: Pallares I]] | ||
[[Category: Reverter | [[Category: Reverter D]] | ||
[[Category: Vendrell | [[Category: Vendrell J]] | ||
Revision as of 10:16, 15 February 2023
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor
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