7r2j: Difference between revisions

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'''Unreleased structure'''


The entry 7r2j is ON HOLD  until Paper Publication
==Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide==
 
<StructureSection load='7r2j' size='340' side='right'caption='[[7r2j]], [[Resolution|resolution]] 1.26&Aring;' scene=''>
Authors: Silva, D.O., Graedler, U., Bandeiras, T.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7r2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2J FirstGlance]. <br>
Description: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=V0Z:N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide'>V0Z</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2j OCA], [https://pdbe.org/7r2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2j RCSB], [https://www.ebi.ac.uk/pdbsum/7r2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2j ProSAT]</span></td></tr>
[[Category: Graedler, U]]
</table>
[[Category: Bandeiras, T.M]]
== Function ==
[[Category: Silva, D.O]]
[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bandeiras TM]]
[[Category: Graedler U]]
[[Category: Silva DO]]
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