2ld7: Difference between revisions

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==Solution structure of the mSin3A PAH3-SAP30 SID complex==

== Structural highlights ==

<table><tr><td colspan='2'>[[2ld7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD7 FirstGlance]. <br>

<table><tr><td colspan='2'>[[2ld7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD7 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sap30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Sin3a, Kiaa4126 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld7 OCA], [https://pdbe.org/2ld7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld7 ProSAT]</span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld7 OCA], [https://pdbe.org/2ld7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld7 ProSAT]</span></td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/SAP30_MOUSE SAP30_MOUSE]] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9702189</ref> [UniProtKB:O75446] [[https://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>

[https://www.uniprot.org/uniprot/SAP30_MOUSE SAP30_MOUSE] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9702189</ref> [UniProtKB:O75446]

== Publication Abstract from PubMed ==

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</StructureSection>

[[Category: Large Structures]]

[[Category: ~~Lk3 transgenic mice~~]]

[[Category: Mus musculus]]

[[Category: He, Y]]

[[Category: He Y]]

[[Category: Imhoff, R]]

[[Category: Imhoff R]]

[[Category: Korkeamaki, H]]

[[Category: Korkeamaki H]]

[[Category: Lohi, O]]

[[Category: Lohi O]]

[[Category: Radhakrishnan, I]]

[[Category: Radhakrishnan I]]

[[Category: Xie, T]]

[[Category: Xie T]]

[[Category: Zhang, Y]]

[[Category: Zhang Y]]

~~[[Category: Transcription~~]]

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@@ Line 1: / Line 1: @@
 ==Solution structure of the mSin3A PAH3-SAP30 SID complex==
-<StructureSection load='2ld7' size='340' side='right'caption='[[2ld7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2ld7' size='340' side='right'caption='[[2ld7]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ld7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ld7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LD7 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sap30 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Sin3a, Kiaa4126 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld7 OCA], [https://pdbe.org/2ld7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld7 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ld7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld7 OCA], [https://pdbe.org/2ld7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ld7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ld7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ld7 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/SAP30_MOUSE SAP30_MOUSE]] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9702189</ref> [UniProtKB:O75446] [[https://www.uniprot.org/uniprot/SIN3A_MOUSE SIN3A_MOUSE]] Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.<ref>PMID:8649810</ref> <ref>PMID:7889570</ref> <ref>PMID:10734093</ref>
+[https://www.uniprot.org/uniprot/SAP30_MOUSE SAP30_MOUSE] Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.<ref>PMID:9702189</ref> [UniProtKB:O75446]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 25: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: He, Y]]
+[[Category: He Y]]
-[[Category: Imhoff, R]]
+[[Category: Imhoff R]]
-[[Category: Korkeamaki, H]]
+[[Category: Korkeamaki H]]
-[[Category: Lohi, O]]
+[[Category: Lohi O]]
-[[Category: Radhakrishnan, I]]
+[[Category: Radhakrishnan I]]
-[[Category: Xie, T]]
+[[Category: Xie T]]
-[[Category: Zhang, Y]]
+[[Category: Zhang Y]]
-[[Category: Transcription]]