2lec: Difference between revisions

<StructureSection load='2lec' size='340' side='right'caption='[[2lec]]' scene=''>

<table><tr><td colspan='2'>[[2lec]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEC FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lec OCA], [https://pdbe.org/2lec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lec RCSB], [https://www.ebi.ac.uk/pdbsum/2lec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lec ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SRSF2_HUMAN SRSF2_HUMAN] Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.<ref>PMID:19592491</ref> <ref>PMID:21157427</ref>  

[[Category: Homo sapiens]]

[[Category: Allain FH-T]]

[[Category: Clery A]]

[[Category: Daubner GM]]

[[Category: Jayne S]]

[[Category: Stevenin J]]