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==Solution NMR structure of N-terminal domain of human E3 ubiquitin-protein ligase HECW2, Northeast structural genomics consortium (NESG) target ht6306A==
==Solution NMR structure of N-terminal domain of human E3 ubiquitin-protein ligase HECW2, Northeast structural genomics consortium (NESG) target ht6306A==
<StructureSection load='2lfe' size='340' side='right'caption='[[2lfe]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
<StructureSection load='2lfe' size='340' side='right'caption='[[2lfe]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFE FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HECW2, KIAA1301, NEDL2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfe OCA], [https://pdbe.org/2lfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfe RCSB], [https://www.ebi.ac.uk/pdbsum/2lfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfe OCA], [https://pdbe.org/2lfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfe RCSB], [https://www.ebi.ac.uk/pdbsum/2lfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HECW2_HUMAN HECW2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.  
[https://www.uniprot.org/uniprot/HECW2_HUMAN HECW2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Arrowsmith C]]
[[Category: Chitayat, S]]
[[Category: Chitayat S]]
[[Category: Dhe-Paganon, S]]
[[Category: Dhe-Paganon S]]
[[Category: Garcia, M]]
[[Category: Garcia M]]
[[Category: Houliston, S]]
[[Category: Houliston S]]
[[Category: Lemak, A]]
[[Category: Lemak A]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Yee A]]
[[Category: Yee, A]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: Psi-biology]]
[[Category: Sgc]]
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