2lr8: Difference between revisions
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==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A== | ==Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A== | ||
<StructureSection load='2lr8' size='340' side='right'caption='[[2lr8 | <StructureSection load='2lr8' size='340' side='right'caption='[[2lr8]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2lr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LR8 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [https://pdbe.org/2lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr8 OCA], [https://pdbe.org/2lr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lr8 RCSB], [https://www.ebi.ac.uk/pdbsum/2lr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lr8 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Eletsky | [[Category: Eletsky A]] | ||
[[Category: Everett | [[Category: Everett JK]] | ||
[[Category: Janjua | [[Category: Janjua H]] | ||
[[Category: Kohan | [[Category: Kohan E]] | ||
[[Category: Lee | [[Category: Lee D]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Pulavarti S]] | |||
[[Category: Pulavarti | [[Category: Sathyamoorthy B]] | ||
[[Category: Sathyamoorthy | [[Category: Sukumaran DK]] | ||
[[Category: Sukumaran | [[Category: Szyperski T]] | ||
[[Category: Szyperski | [[Category: Xiao R]] | ||
[[Category: Xiao | |||
