7pgv: Difference between revisions

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'''Unreleased structure'''


The entry 7pgv is ON HOLD
==H3K36 tri-methylated nucleosome LEDGF PWWP domain complex==
 
<StructureSection load='7pgv' size='340' side='right'caption='[[7pgv]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
Authors: Koutna, E., Lux, V., Novacek, J., Srb, P., Hexnerova, R., Skerlova, J., Poepsel, S., Veverka, V.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7pgv]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGV FirstGlance]. <br>
Description: H3K36 tri-methylated nucleosome LEDGF PWWP domain complex
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgv OCA], [https://pdbe.org/7pgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgv RCSB], [https://www.ebi.ac.uk/pdbsum/7pgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgv ProSAT]</span></td></tr>
[[Category: Veverka, V]]
</table>
[[Category: Novacek, J]]
== Function ==
[[Category: Hexnerova, R]]
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
[[Category: Koutna, E]]
__TOC__
[[Category: Srb, P]]
</StructureSection>
[[Category: Lux, V]]
[[Category: Homo sapiens]]
[[Category: Poepsel, S]]
[[Category: Large Structures]]
[[Category: Skerlova, J]]
[[Category: Synthetic construct]]
[[Category: Xenopus laevis]]
[[Category: Hexnerova R]]
[[Category: Koutna E]]
[[Category: Lux V]]
[[Category: Novacek J]]
[[Category: Poepsel S]]
[[Category: Skerlova J]]
[[Category: Srb P]]
[[Category: Veverka V]]
Retrieved from "https://proteopedia.org/7pgv"