7xk8: Difference between revisions
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==Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25== | |||
<StructureSection load='7xk8' size='340' side='right'caption='[[7xk8]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7xk8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XK8 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xk8 OCA], [https://pdbe.org/7xk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xk8 RCSB], [https://www.ebi.ac.uk/pdbsum/7xk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xk8 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NMU_HUMAN NMU_HUMAN] Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.[UniProtKB:P12760] Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.[UniProtKB:P12760] Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.[UniProtKB:P12760] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Albert B]] | |||
[[Category: Cuiying Y]] | |||
[[Category: Gisela S]] | |||
[[Category: Han S]] | |||
[[Category: Holger W]] | |||
[[Category: Minmin L]] | |||
[[Category: Mu W]] | |||
[[Category: Shutian C]] | |||
[[Category: Tingting T]] | |||
[[Category: Wenru Z]] | |||
[[Category: Wu B]] | |||
[[Category: Xiaojing C]] | |||
[[Category: Zhao Q]] | |||
[[Category: Zhao W]] | |||
Latest revision as of 12:35, 22 February 2023
Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25
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