8b0f: Difference between revisions

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'''Unreleased structure'''


The entry 8b0f is ON HOLD  until Paper Publication
==CryoEM structure of C5b8-CD59==
 
<StructureSection load='8b0f' size='340' side='right'caption='[[8b0f]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Bubeck, D., Couves, E.C., Gardner, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8b0f]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0F FirstGlance]. <br>
Description: CryoEM structure of C5b8-CD59
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0f OCA], [https://pdbe.org/8b0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0f RCSB], [https://www.ebi.ac.uk/pdbsum/8b0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0f ProSAT]</span></td></tr>
[[Category: Couves, E.C]]
</table>
[[Category: Gardner, S]]
== Disease ==
[[Category: Bubeck, D]]
[https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:[https://omim.org/entry/612446 612446]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
== Function ==
[https://www.uniprot.org/uniprot/CO6_HUMAN CO6_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bubeck D]]
[[Category: Couves EC]]
[[Category: Gardner S]]
Retrieved from "https://proteopedia.org/8b0f"