8b0h: Difference between revisions
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==2C9, C5b9-CD59 cryoEM structure== | |||
<StructureSection load='8b0h' size='340' side='right'caption='[[8b0h]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8b0h]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0H FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0h OCA], [https://pdbe.org/8b0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0h RCSB], [https://www.ebi.ac.uk/pdbsum/8b0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0h ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[https://omim.org/entry/612300 612300].<ref>PMID:1382994</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bubeck D]] | |||
[[Category: Couves EC]] | |||
[[Category: Gardner S]] | |||
