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==Structure-functional characterization of Grx domain of Mus musculus TGR==
==Structure-functional characterization of Grx domain of Mus musculus TGR==
<StructureSection load='2lv3' size='340' side='right'caption='[[2lv3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lv3' size='340' side='right'caption='[[2lv3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LV3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LV3 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3h8q|3h8q]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lv3 OCA], [https://pdbe.org/2lv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lv3 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tgr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lv3 OCA], [https://pdbe.org/2lv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lv3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TRXR3_MOUSE TRXR3_MOUSE]] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.<ref>PMID:11259642</ref> <ref>PMID:15901730</ref>
[https://www.uniprot.org/uniprot/TRXR3_MOUSE TRXR3_MOUSE] Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components.<ref>PMID:11259642</ref> <ref>PMID:15901730</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Thioredoxin-disulfide reductase]]
[[Category: Dikiy A]]
[[Category: Dikiy, A]]
[[Category: Dobrovolska O]]
[[Category: Dobrovolska, O]]
[[Category: Gladyshev V]]
[[Category: Gladyshev, V]]
[[Category: Shumilina E]]
[[Category: Shumilina, E]]
[[Category: Grx]]
[[Category: Oxidoreductase]]
[[Category: Tgr]]

Revision as of 13:12, 22 February 2023

Structure-functional characterization of Grx domain of Mus musculus TGR

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