2m19: Difference between revisions
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==Solution structure of the Haloferax volcanii HVO 2177 protein== | ==Solution structure of the Haloferax volcanii HVO 2177 protein== | ||
<StructureSection load='2m19' size='340' side='right'caption='[[2m19 | <StructureSection load='2m19' size='340' side='right'caption='[[2m19]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2m19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2m19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloferax_volcanii_DS2 Haloferax volcanii DS2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M19 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m19 OCA], [https://pdbe.org/2m19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m19 RCSB], [https://www.ebi.ac.uk/pdbsum/2m19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m19 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m19 OCA], [https://pdbe.org/2m19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m19 RCSB], [https://www.ebi.ac.uk/pdbsum/2m19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m19 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SAMP3_HALVD SAMP3_HALVD] Functions as a protein modifier covalently attached to lysine residues of substrate proteins. The protein modification process is termed sampylation and involves the formation of an isopeptide bond between the SAMP3 C-terminal glycine carboxylate and the epsilon-amino group of lysine residues on target proteins. Seems to be able to form polymeric chains with itself at Lys-18, Lys-55 and Lys-62, similar to ubiquitin and other ubiquitin-like proteins. SAMP3 appears not to serve as a proteolytic signal in the cell to target proteins for degradation by proteasomes. May regulate molybdenum cofactor (MoCo) biosynthesis by inhibiting the activity of MPT synthase MoaE under aerobic conditions, providing a hierarchy of oxygen use prior to that of alternative electron acceptors such as DMSO.<ref>PMID:21368171</ref> <ref>PMID:24097257</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Haloferax volcanii DS2]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hao | [[Category: Hao B]] | ||
[[Category: Jin | [[Category: Jin K]] | ||
[[Category: Li | [[Category: Li Y]] | ||
[[Category: Lu | [[Category: Lu M]] | ||
[[Category: Maciejewski | [[Category: Maciejewski MW]] | ||
[[Category: Martin | [[Category: Martin J]] | ||
[[Category: Maupin-Furlow | [[Category: Maupin-Furlow JA]] | ||
[[Category: Zhang | [[Category: Zhang Y]] | ||
