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==Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2==
==Structure of the C-domain of Calcium-saturated Calmodulin bound to the IQ motif of NaV1.2==
<StructureSection load='2m5e' size='340' side='right'caption='[[2m5e]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
<StructureSection load='2m5e' size='340' side='right'caption='[[2m5e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Parte Parte]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M5E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m5e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_tetraurelia Paramecium tetraurelia] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M5E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kxw|2kxw]], [[1exr|1exr]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAM, GSPATT00015825001 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5888 PARTE]), Scn2a, Scn2a1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5e OCA], [https://pdbe.org/2m5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m5e RCSB], [https://www.ebi.ac.uk/pdbsum/2m5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m5e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5e OCA], [https://pdbe.org/2m5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m5e RCSB], [https://www.ebi.ac.uk/pdbsum/2m5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m5e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CALM_PARTE CALM_PARTE]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. [[https://www.uniprot.org/uniprot/SCN2A_RAT SCN2A_RAT]] Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.  
[https://www.uniprot.org/uniprot/CALM_PARTE CALM_PARTE] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Parte]]
[[Category: Paramecium tetraurelia]]
[[Category: Feldkamp, M D]]
[[Category: Rattus norvegicus]]
[[Category: Fowler, C A]]
[[Category: Feldkamp MD]]
[[Category: Shea, M A]]
[[Category: Fowler CA]]
[[Category: Yu, L]]
[[Category: Shea MA]]
[[Category: Calcium binding protein]]
[[Category: Yu L]]
[[Category: Calcium binding protein-metal transport complex]]
[[Category: Calcium-binding protein-metal transport complex]]
[[Category: Ef-hand]]
[[Category: Ion channel gating]]
[[Category: Iq motif]]
[[Category: Metal binding]]
[[Category: Metal transport]]
[[Category: Nav1 2]]
[[Category: Neuronal peptide]]
[[Category: Sodium channel]]
[[Category: Voltage dependent]]
[[Category: Voltage gated]]
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