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==Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500==
==Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500==
<StructureSection load='4qox' size='340' side='right' caption='[[4qox]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='4qox' size='340' side='right'caption='[[4qox]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qox]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QOX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QOX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DXR:3-(3-BROMOBENZYL)-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>DXR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXR:3-(3-BROMOBENZYL)-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>DXR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDPK4, CPK4, PF07_0072 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qox OCA], [https://pdbe.org/4qox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qox RCSB], [https://www.ebi.ac.uk/pdbsum/4qox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qox ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qox OCA], [http://pdbe.org/4qox PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qox RCSB], [http://www.ebi.ac.uk/pdbsum/4qox PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qox ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CDPK4_PLAF7 CDPK4_PLAF7]] Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).  
[https://www.uniprot.org/uniprot/CDPK4_PLAF7 CDPK4_PLAF7] Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
 
==See Also==
*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Plaf7]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Amani, M]]
[[Category: Amani M]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: He, H]]
[[Category: He H]]
[[Category: Hui, R]]
[[Category: Hui R]]
[[Category: Hutchinson, A]]
[[Category: Hutchinson A]]
[[Category: Lin, Y H]]
[[Category: Lin YH]]
[[Category: Loppnau, P]]
[[Category: Loppnau P]]
[[Category: Lovato, D V]]
[[Category: Lovato DV]]
[[Category: Neculai, M]]
[[Category: Neculai M]]
[[Category: Ravichandran, M]]
[[Category: Ravichandran M]]
[[Category: Structural genomic]]
[[Category: Seitova A]]
[[Category: Seitova, A]]
[[Category: Walker JR]]
[[Category: Walker, J R]]
[[Category: Wernimont AK]]
[[Category: Wernimont, A K]]
[[Category: Cdpk]]
[[Category: Malaria]]
[[Category: Plasmodium]]
[[Category: Sgc]]
[[Category: Transferase]]

Revision as of 13:44, 22 February 2023

Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500

4qox, resolution 2.75Å

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