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<StructureSection load='4qpn' size='340' side='right'caption='[[4qpn]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='4qpn' size='340' side='right'caption='[[4qpn]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QPN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">METTL21B, FAM119B, HCA557A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpn OCA], [https://pdbe.org/4qpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpn RCSB], [https://www.ebi.ac.uk/pdbsum/4qpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpn OCA], [http://pdbe.org/4qpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qpn RCSB], [http://www.ebi.ac.uk/pdbsum/4qpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MT21B_HUMAN MT21B_HUMAN]] Protein-lysine methyltransferase (By similarity).  
[https://www.uniprot.org/uniprot/EFMT3_HUMAN EFMT3_HUMAN] Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation.<ref>PMID:28108655</ref> <ref>PMID:28663172</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Brown, P J]]
[[Category: Brown PJ]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Graslund, S]]
[[Category: Graslund S]]
[[Category: He, H]]
[[Category: He H]]
[[Category: Hong, B S]]
[[Category: Hong BS]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Structural genomic]]
[[Category: Seitova A]]
[[Category: Seitova, A]]
[[Category: Tempel W]]
[[Category: Tempel, W]]
[[Category: Sgc]]
[[Category: Transferase]]

Revision as of 13:45, 22 February 2023

Crystal Structure of Human Methyltransferase-Like Protein 21B

4qpn, resolution 1.25Å

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