4qt6: Difference between revisions
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==Crystal structure of the SPRY domain of human HERC1== | ==Crystal structure of the SPRY domain of human HERC1== | ||
<StructureSection load='4qt6' size='340' side='right' caption='[[4qt6]], [[Resolution|resolution]] 1.64Å' scene=''> | <StructureSection load='4qt6' size='340' side='right'caption='[[4qt6]], [[Resolution|resolution]] 1.64Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4qt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QT6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand= | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARF:FORMAMIDE'>ARF</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qt6 OCA], [https://pdbe.org/4qt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qt6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qt6 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/HERC1_HUMAN HERC1_HUMAN] Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.<ref>PMID:8861955</ref> <ref>PMID:9233772</ref> <ref>PMID:15642342</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Dong | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Dong A]] | ||
[[Category: Guan | [[Category: Edwards AM]] | ||
[[Category: Hu | [[Category: Guan X]] | ||
[[Category: Li | [[Category: Hu J]] | ||
[[Category: Li Y]] | |||
[[Category: Tong | [[Category: Tong Y]] | ||
[[Category: Wernimont | [[Category: Wernimont A]] | ||
