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==crystal structure of human LGR4 and Rspo1==
==crystal structure of human LGR4 and Rspo1==
<StructureSection load='4qxf' size='340' side='right' caption='[[4qxf]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='4qxf' size='340' side='right'caption='[[4qxf]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qxf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QXF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qxf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QXF FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPR48, LGR4, VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri]), RSPO1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxf OCA], [https://pdbe.org/4qxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qxf RCSB], [https://www.ebi.ac.uk/pdbsum/4qxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxf OCA], [http://pdbe.org/4qxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qxf RCSB], [http://www.ebi.ac.uk/pdbsum/4qxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qxf ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Palmoplantar keratoderma - XX sex reversal - predisposition to squamous cell carcinoma. Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:[http://omim.org/entry/610644 610644]]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LGR4_HUMAN LGR4_HUMAN]] Orphan receptor. [[http://www.uniprot.org/uniprot/RSPO1_HUMAN RSPO1_HUMAN]] Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.<ref>PMID:16109882</ref> <ref>PMID:22575959</ref> 
[https://www.uniprot.org/uniprot/LGR4_HUMAN LGR4_HUMAN] Orphan receptor.[https://www.uniprot.org/uniprot/Q4G1L2_EPTBU Q4G1L2_EPTBU]  
== References ==
 
<references/>
==See Also==
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bdellostoma burgeri]]
[[Category: Eptatretus burgeri]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Huang, C]]
[[Category: Large Structures]]
[[Category: Xu, J G]]
[[Category: Huang C]]
[[Category: Zhou, Y]]
[[Category: Xu JG]]
[[Category: Zhu, Y]]
[[Category: Zhou Y]]
[[Category: Beta-hairpin]]
[[Category: Zhu Y]]
[[Category: Cell membrane]]
[[Category: Glucosylation]]
[[Category: Ligand-receptor complex]]
[[Category: Lrr repeat]]
[[Category: Membrane protein]]

Revision as of 13:58, 22 February 2023

crystal structure of human LGR4 and Rspo1

4qxf, resolution 2.25Å

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