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| **[[5ayp]] – FPS – ''Geobacillus stearothermophilus''<br /> | | **[[5ayp]] – FPS – ''Geobacillus stearothermophilus''<br /> |
| **[[6ww1]] – LmFPS (mutant) – ''Leishmania major''<br /> | | **[[6ww1]] – LmFPS (mutant) – ''Leishmania major''<br /> |
| | **[[4ryp]] – TbFPS –''Trypanosoma brucei''<br /> |
| | **[[3ts7]] – FPS – ''Methylococcus capsulatus''<br /> |
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| *FPS binary complexes | | *FPS binary complexes |
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| **[[5hxp]] – z,z-FPS (mutant) + IPP<br /> | | **[[5hxp]] – z,z-FPS (mutant) + IPP<br /> |
| **[[5hxq]] – z,z-FPS (mutant) + DMSPP<br /> | | **[[5hxq]] – z,z-FPS (mutant) + DMSPP<br /> |
| **[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br /> | | **[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]], [[4rxe]], [[5ael]], [[5afx]] - TbFPS + inhibitor <br /> |
| | **[[4rxd]] – TbFBS + risedronate <br /> |
| **[[2for]]– FPS + IPP – ''Shigella flexneri''<br /> | | **[[2for]]– FPS + IPP – ''Shigella flexneri''<br /> |
| **[[4jzb]], [[4jzx]], [[4k10]] – Leshmaniasis major FPS + inhibitor<br /> | | **[[4jzb]], [[4jzx]], [[4k10]] – Leshmaniasis major FPS + inhibitor<br /> |
| **[[3id0]], [[3iba]], [[3ick]], [[3icm]], [[3icn]], [[3icz]], [[5qpd]], [[6sdn]], [[6sdo]], [[6sdp]], [[6sdq]], [[6sf8]], [[6sf9]], [[6shv]], [[6si5]] – TcFPS + inhibitor<br /> | | **[[3id0]], [[3iba]], [[3ick]], [[3icm]], [[3icn]], [[3icz]], [[4rxc]], [[5ahu]], [[5qpd]], [[6sdn]], [[6sdo]], [[6sdp]], [[6sdq]], [[6sf8]], [[6sf9]], [[6shv]], [[6si5]] – TcFPS + inhibitor<br /> |
| **[[6t7n]] – TcFPS + IPP<br /> | | **[[6t7n]] – TcFPS + IPP<br /> |
| **[[5qpe]], [[5qpk]], [[5qpo]], [[5qq3]], [[5qq8]] – TcFPS + imidazole inhibitor<br /> | | **[[5qpe]], [[5qpk]], [[5qpo]], [[5qq3]], [[5qq8]] – TcFPS + imidazole inhibitor<br /> |
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| **[[3pde]] – LbFPS + IPP<br /> | | **[[3pde]] – LbFPS + IPP<br /> |
| **[[6vjc]] – LmFPS (mutant) + inhibitor<br /> | | **[[6vjc]] – LmFPS (mutant) + inhibitor<br /> |
| | **[[4llt]] - RdFPS + IPP – ''Roseobacter denitrificans''<br /> |
| | **[[7my6]] - FPS + IPP – ''Synechococcus elongatus<''br /> |
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| *FPS ternary complexes | | *FPS ternary complexes |
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| **[[3ez3]] - PvFPS + IPP + inhibitor – ''Plasmodium vivax''<br /> | | **[[3ez3]] - PvFPS + IPP + inhibitor – ''Plasmodium vivax''<br /> |
| **[[3dyf]] - TbFPS + IPP + inhibitor<br /> | | **[[3dyf]] - TbFPS + IPP + inhibitor<br /> |
| | **[[4lls]] - RdFPS + IPP + geranyl derivative <br /> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |
3D structures of farnesyl diphosphate synthase
Updated on 27-February-2023
{"openlevels":0}
- Farnesyl diphosphate synthase
- 1zw5, 2f7m, 4xqr, 4xqs, 4xqt – hFPS – human
- 1fps– cFPS – chicken
- 1ubv – cFPS (mutant)
- 5hxn – z,z-FPS – tomato
- 5hxo – z,z-FPS (mutant)
- 1rtr– FPS – Staphylococcus aureus
- 1yhk, 5qqc, 6r04, 3iba, 3icz, 3icm, 3icn, 1yhl, 6se2, 6sfa – TcFPPS – Trypanosoma cruzi
- 6vjc, 6w71, 4k10, 4jzb, 4jzx– LmFPPS – Leishmania major
- 3lvs, 3m0g – FPS – Rhodobacter capsulatus
- 3m9u – LbFPS – Lactobacillus brevis
- 5ayp – FPS – Geobacillus stearothermophilus
- 6ww1 – LmFPS (mutant) – Leishmania major
- 4ryp – TbFPS –Trypanosoma brucei
- 3ts7 – FPS – Methylococcus capsulatus
- FPS binary complexes
- 1yq7, 1yv5, 2f89, 2f8c, 2f92, 2f94, 2f9k, 2rah, 2opn, 2vf6, 3b7l, 2opm, 3n1v, 3n1w, 3n3l, 3n45, 3n46, 3n49, 3n5j, 3n6k, 3n5h, 4dem, 4ga3, 4jvj, 4pvx, 4pvy, 4rxa, 5dgn, 5diq, 5djp, 5djr, 5djv, 5juz, 5jv0, 5jv1, 5jv2, 5ksx, 5ygi, 6n7y, 6n7z, 6n82, 6n83, 6oag, 6oah - hFPS + inhibitor
- 2qis, 3cp6, 3rye, 3s4j, 4n9u - hFPS (mutant) + inhibitor
- 4kfa, 4kpj, 4kq5 - hFPS (mutant) + osteoporosis drug
- 4lpg, 4lph, 4n1z, 4p0x - hFPS + drug
- 4nfi, 4nfj, 4nfk, 4qxs, 4qpf, 5cg5 - hFPS + bisphosphonate
- 4ng6, 4nke, 4nkf, 4nua, 4ogu, 4q23 - hFPS (mutant) + bisphosphonate
- 5dgm, 5dgs - hFPS + monophosphonate
- 5ja0 - hFPS + FPP
- 1ubw, 1ubx - cFPS (mutant) + GDP
- 1uby - cFPS (mutant) + dimethylallyl PP
- 6b07, 6b02, 6b04, 6b06 – FPS + inhibitor – spruce budworm moth
- 5hxp – z,z-FPS (mutant) + IPP
- 5hxq – z,z-FPS (mutant) + DMSPP
- 2i19, 2ewg, 2ogd, 2p1c, 3dyg, 3dyh, 3efq, 3egt, 4rxe, 5ael, 5afx - TbFPS + inhibitor
- 4rxd – TbFBS + risedronate
- 2for– FPS + IPP – Shigella flexneri
- 4jzb, 4jzx, 4k10 – Leshmaniasis major FPS + inhibitor
- 3id0, 3iba, 3ick, 3icm, 3icn, 3icz, 4rxc, 5ahu, 5qpd, 6sdn, 6sdo, 6sdp, 6sdq, 6sf8, 6sf9, 6shv, 6si5 – TcFPS + inhibitor
- 6t7n – TcFPS + IPP
- 5qpe, 5qpk, 5qpo, 5qq3, 5qq8 – TcFPS + imidazole inhibitor
- 5qpg, 5qpn, 6r08 – TcFPS + indole inhibitor
- 5qpf, 5qq1, 6r09, 6r0a, 6r0b – TcFPS + piperazine inhibitor
- 6r06 – TcFPS + piperidine inhibitor
- 5qph, 5qq0 – TcFPS + morpholine inhibitor
- 5qpi, 5qpw, 5qpy, 5qq5, 5qqa – TcFPS + pyrazole inhibitor
- 5qps – TcFPS + oxazole inhibitor
- 5qpj, 5qpu, 5qq9 – TcFPS + acetamide inhibitor
- 5qpq – TcFPS + ethanamide inhibitor
- 5qpv – TcFPS + caboxamide inhibitor
- 5qpl, 5qpm, 5qpp, 5qpr, 5qpz, 5qq4 – TcFPS + urea inhibitor
- 5qpt – TcFPS + thiazine inhibitor
- 5qq2, 6r07 – TcFPS + thiophene inhibitor
- 5qpx – TcFPS + quinoline inhibitor
- 5qq6, 5qq7 – TcFPS + pyrrolidine inhibitor
- 6r05 – TcFPS + pyridine inhibitor
- 5qqb – TcFPS + benzodiazo inhibitor
- 3pde – LbFPS + IPP
- 6vjc – LmFPS (mutant) + inhibitor
- 4llt - RdFPS + IPP – Roseobacter denitrificans
- 7my6 - FPS + IPP – Synechococcus elongatus<br />
- FPS ternary complexes
- 2f8z, 4h5e - hFPS + IPP + inhibitor
- 4kpd, 4kqs, 4kqu - hFPS (mutant) + IPP + osteoporosis drug
- 4p0v, 4p0w - hFPS + 2 drugs
- 4h5c, 4h3c, 4h5d, 4lfv - hFPS + phosphate + inhibitor
- 5cg6 - hFPS + IPP + bisphosphonate
- 4l2x - hFPS + PP + inhibitor
- 5hxt – z,z-FPS (mutant) + DMSPP + IPP
- 1rqi – EcFPS + IPP + dimethylallyl S-thioloPP – Escherichia coli
- 1rqj - EcFPS + IPP + inhibitor
- 1yhl – TcFPS + dimethylallyl PP + inhibitor
- 1yhm, 3iba, 3ick, 3icm, 3icn, 3icz, 4dwb, 4dwg, 4dxj, 4dzw, 4e1e - TcFPS + IPP + inhibitor
- 3ez3 - PvFPS + IPP + inhibitor – Plasmodium vivax
- 3dyf - TbFPS + IPP + inhibitor
- 4lls - RdFPS + IPP + geranyl derivative
