|
|
| Line 1: |
Line 1: |
| | | #REDIRECT [[6hl1]] This PDB entry is obsolete and replaced by 6hl1 |
| ==FXR with CDCA and NCoA-2 peptide==
| |
| <StructureSection load='4qe6' size='340' side='right'caption='[[4qe6]], [[Resolution|resolution]] 1.65Å' scene=''>
| |
| == Structural highlights ==
| |
| <table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>
| |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
| |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [https://pdbe.org/4qe6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>
| |
| </table>
| |
| == Function ==
| |
| [https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
| |
| | |
| ==See Also==
| |
| *[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
| |
| == References ==
| |
| <references/>
| |
| __TOC__
| |
| </StructureSection>
| |
| [[Category: Homo sapiens]]
| |
| [[Category: Large Structures]]
| |
| [[Category: Bamberg K]]
| |
| [[Category: Dekker N]]
| |
| [[Category: Kudlinzki D]]
| |
| [[Category: Linhard VL]]
| |
| [[Category: Merk D]]
| |
| [[Category: Nilsson E]]
| |
| [[Category: Saxena K]]
| |
| [[Category: Schubert-Zsilavecz M]]
| |
| [[Category: Schwalbe H]]
| |
| [[Category: Sreeramulu S]]
| |
| [[Category: Wissler L]]
| |
