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==The protein complex for DNA replication==
==The protein complex for DNA replication==
<StructureSection load='2le8' size='340' side='right'caption='[[2le8]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''>
<StructureSection load='2le8' size='340' side='right'caption='[[2le8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2le8]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LE8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2le8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LE8 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2le8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2le8 OCA], [https://pdbe.org/2le8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2le8 RCSB], [https://www.ebi.ac.uk/pdbsum/2le8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2le8 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2le8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2le8 OCA], [https://pdbe.org/2le8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2le8 RCSB], [https://www.ebi.ac.uk/pdbsum/2le8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2le8 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/CDT1_HUMAN CDT1_HUMAN]] Defects in CDT1 are the cause of Meier-Gorlin syndrome type 4 (MGORS4) [MIM:[https://omim.org/entry/613804 613804]]. MGORS4 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref> <ref>PMID:21358631</ref> 
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MCM6_HUMAN MCM6_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:9305914</ref> [[https://www.uniprot.org/uniprot/CDT1_HUMAN CDT1_HUMAN]] Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.<ref>PMID:11125146</ref> <ref>PMID:21856198</ref> <ref>PMID:14672932</ref> <ref>PMID:14993212</ref> [UniProtKB:Q8R4E9]
[https://www.uniprot.org/uniprot/MCM6_HUMAN MCM6_HUMAN] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:9305914</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Liu, C]]
[[Category: Liu C]]
[[Category: Wei, Z]]
[[Category: Wei Z]]
[[Category: Zhu, G]]
[[Category: Zhu G]]
[[Category: Dna replication]]
[[Category: Replication]]

Revision as of 06:26, 2 March 2023

The protein complex for DNA replication

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