2m99: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:


==Solution structure of a chymotrypsin inhibitor from the Taiwan cobra==
==Solution structure of a chymotrypsin inhibitor from the Taiwan cobra==
<StructureSection load='2m99' size='340' side='right'caption='[[2m99]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2m99' size='340' side='right'caption='[[2m99]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ansp_6988 Ansp 6988]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M99 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M99 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aci ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8656 ANSP 6988])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m99 OCA], [https://pdbe.org/2m99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m99 RCSB], [https://www.ebi.ac.uk/pdbsum/2m99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m99 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m99 OCA], [https://pdbe.org/2m99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m99 RCSB], [https://www.ebi.ac.uk/pdbsum/2m99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m99 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VKT_NAJAT VKT_NAJAT] Serine protease inhibitor that inhibits chymotrypsin (Ki=25 nM) (PubMed:15698956, PubMed:14990218). Also interacts with vasopressin V2 receptor (V2R/AVPR2) (PubMed:35122240). Inhibits vasopressin binding human V2R in the nanomolar range (Ki=112 nM), and also moderately inhibits vasopressin-induced cAMP production (IC(50)=138 nM). In vivo, intraperitoneal injection of this protein into rats increases diuresis by 2.2-fold, without any loss of electrolytes (PubMed:35122240).<ref>PMID:14990218</ref> <ref>PMID:15698956</ref> <ref>PMID:35122240</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 21:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ansp 6988]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chang, L S]]
[[Category: Naja atra]]
[[Category: Guntert, P]]
[[Category: Chang L-S]]
[[Category: Ikeya, T]]
[[Category: Guntert P]]
[[Category: Lin, Y J]]
[[Category: Ikeya T]]
[[Category: Chymotrypsin inhibitor]]
[[Category: Lin Y-J]]
[[Category: Hydrolase inhibitor]]
[[Category: Naci]]
[[Category: Naja naja atra]]
Retrieved from "https://proteopedia.org/2m99"