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==Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A==
==Solution NMR Structure of the RING finger domain from the Kip1 ubiquitination-promoting E3 complex protein 1 (KPC1/RNF123) from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8700A==
<StructureSection load='2ma6' size='340' side='right'caption='[[2ma6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ma6' size='340' side='right'caption='[[2ma6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ma6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ma6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FP1477, KPC1, RNF123 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma6 OCA], [https://pdbe.org/2ma6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma6 OCA], [https://pdbe.org/2ma6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma6 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RN123_HUMAN RN123_HUMAN]] Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.<ref>PMID:15531880</ref> <ref>PMID:16227581</ref>
[https://www.uniprot.org/uniprot/RN123_HUMAN RN123_HUMAN] Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.<ref>PMID:15531880</ref> <ref>PMID:16227581</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Acton, T B]]
[[Category: Acton TB]]
[[Category: Everett, J K]]
[[Category: Everett JK]]
[[Category: Janjua, H]]
[[Category: Janjua H]]
[[Category: Kennedy, M A]]
[[Category: Kennedy MA]]
[[Category: Kohan, E]]
[[Category: Kohan E]]
[[Category: Montelione, G T]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Ramelot TA]]
[[Category: Ramelot, T A]]
[[Category: Wang H]]
[[Category: Wang, H]]
[[Category: Xiao R]]
[[Category: Xiao, R]]
[[Category: Yang Y]]
[[Category: Yang, Y]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Ring fing domain]]
[[Category: Zinc binding protein]]
Retrieved from "https://proteopedia.org/2ma6"