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==NMR structures of the alpha7 nAChR transmembrane domain.==
==NMR structures of the alpha7 nAChR transmembrane domain.==
<StructureSection load='2maw' size='340' side='right'caption='[[2maw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2maw' size='340' side='right'caption='[[2maw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2maw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MAW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2maw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MAW FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRFAM7A, CHRNA7, NACHRA7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2maw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2maw OCA], [https://pdbe.org/2maw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2maw RCSB], [https://www.ebi.ac.uk/pdbsum/2maw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2maw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2maw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2maw OCA], [https://pdbe.org/2maw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2maw RCSB], [https://www.ebi.ac.uk/pdbsum/2maw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2maw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] 15q13.3 microdeletion syndrome.
[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] 15q13.3 microdeletion syndrome.  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.  
[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bondarenko, V]]
[[Category: Bondarenko V]]
[[Category: Mowrey, D]]
[[Category: Mowrey D]]
[[Category: Tang, P]]
[[Category: Tang P]]
[[Category: Xu, Y]]
[[Category: Xu Y]]
[[Category: Membrane protein]]
[[Category: Transmembrane domain]]
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