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==NMR structure of SRA1p C-terminal domain==
==NMR structure of SRA1p C-terminal domain==
<StructureSection load='2mgx' size='340' side='right'caption='[[2mgx]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2mgx' size='340' side='right'caption='[[2mgx]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mgx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGX FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mgx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGX FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRA1, PP7684 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgx OCA], [https://pdbe.org/2mgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgx RCSB], [https://www.ebi.ac.uk/pdbsum/2mgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgx OCA], [https://pdbe.org/2mgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgx RCSB], [https://www.ebi.ac.uk/pdbsum/2mgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SRA1_HUMAN SRA1_HUMAN]] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.<ref>PMID:10199399</ref> <ref>PMID:12943696</ref> <ref>PMID:14517287</ref> <ref>PMID:15351741</ref> <ref>PMID:15147866</ref>
[https://www.uniprot.org/uniprot/SRA1_HUMAN SRA1_HUMAN] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.<ref>PMID:10199399</ref> <ref>PMID:12943696</ref> <ref>PMID:14517287</ref> <ref>PMID:15351741</ref> <ref>PMID:15147866</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bilinovich, S M]]
[[Category: Bilinovich SM]]
[[Category: Buchan, G J]]
[[Category: Buchan GJ]]
[[Category: Davis, C M]]
[[Category: Davis CM]]
[[Category: Leeper, T C]]
[[Category: Leeper TC]]
[[Category: Morris, D L]]
[[Category: Morris DL]]
[[Category: Prokop, J W]]
[[Category: Prokop JW]]
[[Category: Ray, L A]]
[[Category: Ray LA]]
[[Category: Unknown function]]
Retrieved from "https://proteopedia.org/2mgx"