4glp: Difference between revisions
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<StructureSection load='4glp' size='340' side='right'caption='[[4glp]], [[Resolution|resolution]] 4.00Å' scene=''> | <StructureSection load='4glp' size='340' side='right'caption='[[4glp]], [[Resolution|resolution]] 4.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4glp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLP FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [https://pdbe.org/4glp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [https://www.ebi.ac.uk/pdbsum/4glp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glp OCA], [https://pdbe.org/4glp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glp RCSB], [https://www.ebi.ac.uk/pdbsum/4glp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CD14_HUMAN CD14_HUMAN] In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.<ref>PMID:23264655</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kelley | [[Category: Kelley SL]] | ||
[[Category: Lukk | [[Category: Lukk T]] | ||
[[Category: Nair | [[Category: Nair SK]] | ||
[[Category: Tapping | [[Category: Tapping RI]] | ||
