4r87: Difference between revisions
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==Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with CoA and spermine== | ==Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with CoA and spermine== | ||
<StructureSection load='4r87' size='340' side='right' caption='[[4r87]], [[Resolution|resolution]] 2.61Å' scene=''> | <StructureSection load='4r87' size='340' side='right'caption='[[4r87]], [[Resolution|resolution]] 2.61Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4r87]] is a 12 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4r87]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1_biovar_El_Tor_str._N16961 Vibrio cholerae O1 biovar El Tor str. N16961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R87 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r87 OCA], [https://pdbe.org/4r87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r87 RCSB], [https://www.ebi.ac.uk/pdbsum/4r87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r87 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ATDA_VIBCH ATDA_VIBCH] Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine. It can use polyamines such as spermine and N(1)-acetylspermine, but not putrescine or cadaverine.<ref>PMID:23184347</ref> <ref>PMID:25623305</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4r87" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4r87" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Spermidine/spermine N-acetyltransferase|Spermidine/spermine N-acetyltransferase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Vibrio cholerae O1 biovar El Tor str. N16961]] | ||
[[Category: | [[Category: Anderson WF]] | ||
[[Category: Filippova | [[Category: Filippova EV]] | ||
[[Category: Kiryukhina | [[Category: Kiryukhina O]] | ||
[[Category: Kuhn | [[Category: Kuhn ML]] | ||
[[Category: Minasov | [[Category: Minasov G]] | ||
