4r8y: Difference between revisions

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<StructureSection load='4r8y' size='340' side='right'caption='[[4r8y]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4r8y' size='340' side='right'caption='[[4r8y]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r8y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R8Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3KO:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-5-{[(3R)-1-(CYCLOPENTYLACETYL)PYRROLIDIN-3-YL]METHYL}-2-IMINO-3-METHYLIMIDAZOLIDIN-4-ONE'>3KO</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3KO:(2E,5R)-5-(2-CYCLOHEXYLETHYL)-5-{[(3R)-1-(CYCLOPENTYLACETYL)PYRROLIDIN-3-YL]METHYL}-2-IMINO-3-METHYLIMIDAZOLIDIN-4-ONE'>3KO</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r91|4r91]], [[4r92|4r92]], [[4r93|4r93]], [[4r95|4r95]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8y OCA], [https://pdbe.org/4r8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8y RCSB], [https://www.ebi.ac.uk/pdbsum/4r8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8y ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8y OCA], [http://pdbe.org/4r8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r8y RCSB], [http://www.ebi.ac.uk/pdbsum/4r8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Memapsin 2]]
[[Category: Caldwell JP]]
[[Category: Caldwell, J P]]
[[Category: Orth P]]
[[Category: Orth, P]]
[[Category: Strickland C]]
[[Category: Strickland, C]]
[[Category: Aspartyl protease]]
[[Category: Beta-site amyloid precursor protein cleaving enzyme 1]]
[[Category: Beta-site app cleaving enzyme 1]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
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