4rag: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4rag' size='340' side='right'caption='[[4rag]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4rag' size='340' side='right'caption='[[4rag]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rag]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RAG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ra2|4ra2]], [[4raf|4raf]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rag OCA], [https://pdbe.org/4rag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rag RCSB], [https://www.ebi.ac.uk/pdbsum/4rag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rag ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPM1A, PPPM1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rag OCA], [http://pdbe.org/4rag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rag RCSB], [http://www.ebi.ac.uk/pdbsum/4rag PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rag ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN]] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref>
[https://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 20:


==See Also==
==See Also==
*[[Protein phosphatase|Protein phosphatase]]
*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Liu HD]]
[[Category: Liu, H D]]
[[Category: Meng FG]]
[[Category: Meng, F G]]
[[Category: Pan C]]
[[Category: Pan, C]]
[[Category: Sun JP]]
[[Category: Sun, J P]]
[[Category: Tang JY]]
[[Category: Tang, J Y]]
[[Category: Wang HA]]
[[Category: Wang, H A]]
[[Category: Wang WB]]
[[Category: Wang, W B]]
[[Category: Xiao P]]
[[Category: Xiao, P]]
[[Category: Xu YF]]
[[Category: Xu, Y F]]
[[Category: Yu X]]
[[Category: Yu, X]]
[[Category: Metal binding protein]]
[[Category: Phosphatation]]
[[Category: Pp2c family]]
[[Category: Serine/threonine phosphatase]]
Retrieved from "https://proteopedia.org/4rag"