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==Porphyromonas gingivalis gingipain K (Kgp) catalytic and immunoglobulin superfamily-like domains==
==Porphyromonas gingivalis gingipain K (Kgp) catalytic and immunoglobulin superfamily-like domains==
<StructureSection load='4rbm' size='340' side='right' caption='[[4rbm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='4rbm' size='340' side='right'caption='[[4rbm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rbm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33277 Atcc 33277]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RBM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rbm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CKC:(3S)-3,7-DIAMINOHEPTAN-2-ONE'>CKC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CKC:(3S)-3,7-DIAMINOHEPTAN-2-ONE'>CKC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ief|4ief]], [[1cvr|1cvr]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbm OCA], [https://pdbe.org/4rbm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbm RCSB], [https://www.ebi.ac.uk/pdbsum/4rbm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbm ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kgp, prtK, prtP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=837 ATCC 33277])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Gingipain_K Gingipain K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.47 3.4.22.47] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbm OCA], [http://pdbe.org/4rbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rbm RCSB], [http://www.ebi.ac.uk/pdbsum/4rbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KGP83_PORGN KGP83_PORGN]] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]  
[https://www.uniprot.org/uniprot/KGP83_PORGN KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4rbm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4rbm" style="background-color:#fffaf0;"></div>
==See Also==
*[[Proteinase 3D structures|Proteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 33277]]
[[Category: Large Structures]]
[[Category: Gingipain K]]
[[Category: Porphyromonas gingivalis]]
[[Category: Diego, I de]]
[[Category: Gomis-Ruth FX]]
[[Category: Gomis-Ruth, F X]]
[[Category: Guevara T]]
[[Category: Guevara, T]]
[[Category: Huntington JA]]
[[Category: Huntington, J A]]
[[Category: Pomowski A]]
[[Category: Pomowski, A]]
[[Category: Potempa B]]
[[Category: Potempa, B]]
[[Category: Potempa J]]
[[Category: Potempa, J]]
[[Category: Sztukowska MN]]
[[Category: Sztukowska, M N]]
[[Category: Veillard F]]
[[Category: Veillard, F]]
[[Category: De Diego I]]
[[Category: Alpha/beta-hydrolase]]
[[Category: Cysteine peptidase]]
[[Category: Extracellular]]
[[Category: Hydrolase]]
[[Category: Lysine-containing substrate]]
[[Category: Secreted]]
Retrieved from "https://proteopedia.org/4rbm"