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==Crystal Structure of TR3 LBD in complex with Molecule 6==
==Crystal Structure of TR3 LBD in complex with Molecule 6==
<StructureSection load='4ree' size='340' side='right' caption='[[4ree]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
<StructureSection load='4ree' size='340' side='right'caption='[[4ree]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ree]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4REE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4REE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ree]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4REE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4REE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3MZ:1-(2,3,4-TRIHYDROXYPHENYL)NONAN-1-ONE'>3MZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3MZ:1-(2,3,4-TRIHYDROXYPHENYL)NONAN-1-ONE'>3MZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4re8|4re8]], [[4ref|4ref]], [[4whg|4whg]], [[4whf|4whf]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ree FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ree OCA], [https://pdbe.org/4ree PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ree RCSB], [https://www.ebi.ac.uk/pdbsum/4ree PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ree ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GFRP1, HMR, NAK1, NR4A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ree FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ree OCA], [http://pdbe.org/4ree PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ree RCSB], [http://www.ebi.ac.uk/pdbsum/4ree PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ree ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Cai, Q X]]
[[Category: Large Structures]]
[[Category: Hou, P P]]
[[Category: Cai QX]]
[[Category: Li, A Z]]
[[Category: Hou PP]]
[[Category: Li, F W]]
[[Category: Li AZ]]
[[Category: Lin, T W]]
[[Category: Li FW]]
[[Category: Tian, X Y]]
[[Category: Lin TW]]
[[Category: Wang, W J]]
[[Category: Tian XY]]
[[Category: Wu, Q]]
[[Category: Wang WJ]]
[[Category: Yuan, W]]
[[Category: Wu Q]]
[[Category: Lbd]]
[[Category: Yuan W]]
[[Category: Transcription]]
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