4rhx: Difference between revisions

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<StructureSection load='4rhx' size='340' side='right'caption='[[4rhx]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='4rhx' size='340' side='right'caption='[[4rhx]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4rhx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RHX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QF:[2-([2-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)ETHYL]{2-[(2-OXOETHYL)(2-PHOSPHONOETHYL)AMINO]ETHYL}AMINO)ETHYL]PHOSPHONIC+ACID'>3QF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [http://pdbe.org/4rhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [http://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhx OCA], [https://pdbe.org/4rhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhx RCSB], [https://www.ebi.ac.uk/pdbsum/4rhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HGPRT_MYCTU HGPRT_MYCTU] Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi (PubMed:19362594, PubMed:25915781). Thus, specifically recycles hypoxanthine and guanine imported from the external medium, and converts them to IMP and GMP, respectively. Cannot use xanthine as substrate (PubMed:19362594).<ref>PMID:19362594</ref> <ref>PMID:25915781</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4rhx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4rhx" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Eng, W S]]
[[Category: Mycobacterium tuberculosis H37Ra]]
[[Category: Guddat, L W]]
[[Category: Eng WS]]
[[Category: Hockova, D]]
[[Category: Guddat LW]]
[[Category: Keough, D T]]
[[Category: Hockova D]]
[[Category: Naesens, L M.J]]
[[Category: Keough DT]]
[[Category: Spacek, P]]
[[Category: Naesens LMJ]]
[[Category: West, N P]]
[[Category: Spacek P]]
[[Category: Woods, K]]
[[Category: West NP]]
[[Category: 6-oxopurine phosphoribosyltransferase]]
[[Category: Woods K]]
[[Category: Cytoplasmic]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4rhx"