4rke: Difference between revisions

Revision as of 07:00, 2 March 2023

Drosophila melanogaster Rab2 bound to GMPPNP

Structural highlights

4rke is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	1PE, GNP, MG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O18333_DROME

Publication Abstract from PubMed

Rab GTPases belong to the large family of Ras proteins. They act as key regulators of membrane organization and intracellular trafficking. Functionally, they act as switches. In the active GTP-bound form they can bind to effector proteins to facilitate the delivery of transport vesicles. Upon stimulation, the GTP is hydrolyzed and the Rab proteins undergo conformational changes in their switch regions. This study focuses on Rab2 and Rab3 from Drosophila melanogaster. Whereas Rab2 is involved in vesicle transport between the Golgi and the endoplasmatic reticulum, Rab3 is a key player in exocytosis, and in the synapse it is involved in the assembly of the presynaptic active zone. Here, high-resolution crystal structures of Rab2 and Rab3 in complex with GMPPNP and Mg(2+) are presented. In the structure of Rab3 a modified cysteine residue is observed with an enigmatic electron density attached to its thiol function.

Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.,Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):34-40. doi:, 10.1107/S2053230X1402617X. Epub 2015 Jan 1. PMID:25615965^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B. Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):34-40. doi:, 10.1107/S2053230X1402617X. Epub 2015 Jan 1. PMID:25615965 doi:https://dx.doi.org/10.1107/S2053230X1402617X

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Lardong JA, Driller JH, Depner H, Weise C, Petzoldt A, Wahl MC, Sigrist SJ, Loll B. Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):34-40. doi:, 10.1107/S2053230X1402617X. Epub 2015 Jan 1. PMID:25615965 doi:https://dx.doi.org/10.1107/S2053230X1402617X

[1]

@@ Line 3: / Line 3: @@
 <StructureSection load='4rke' size='340' side='right'caption='[[4rke]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4rke]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RKE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4rke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RKE FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z0a|1z0a]], [[4rkf|4rkf]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rke OCA], [https://pdbe.org/4rke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rke RCSB], [https://www.ebi.ac.uk/pdbsum/4rke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rke ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rab2, CG3269, Dmel_CG3269 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rke OCA], [http://pdbe.org/4rke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rke RCSB], [http://www.ebi.ac.uk/pdbsum/4rke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rke ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O18333_DROME O18333_DROME]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
 [[Category: Large Structures]]
-[[Category: Depner, H]]
+[[Category: Depner H]]
-[[Category: Driller, J H]]
+[[Category: Driller JH]]
-[[Category: Lardong, J A]]
+[[Category: Lardong JA]]
-[[Category: Loll, B]]
+[[Category: Loll B]]
-[[Category: Petzoldt, A]]
+[[Category: Petzoldt A]]
-[[Category: Sigrist, S J]]
+[[Category: Sigrist SJ]]
-[[Category: Wahl, M C]]
+[[Category: Wahl MC]]
-[[Category: Weise, C]]
+[[Category: Weise C]]
-[[Category: Gtp hydrolysis]]
-[[Category: Hydrolase]]

4rke: Difference between revisions

Revision as of 07:00, 2 March 2023

Drosophila melanogaster Rab2 bound to GMPPNP

Structural highlights

Function

Publication Abstract from PubMed

References

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