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==Solution structure of the human chemokine CCL19==
==Solution structure of the human chemokine CCL19==
<StructureSection load='2mp1' size='340' side='right'caption='[[2mp1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mp1' size='340' side='right'caption='[[2mp1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MP1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MP1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL19, ELC, MIP3B, SCYA19 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp1 OCA], [https://pdbe.org/2mp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mp1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mp1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp1 OCA], [https://pdbe.org/2mp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mp1 RCSB], [https://www.ebi.ac.uk/pdbsum/2mp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mp1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN]] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref>
[https://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gabel-Eissens, S J]]
[[Category: Gabel-Eissens SJ]]
[[Category: Gillitzer, M L]]
[[Category: Gillitzer ML]]
[[Category: Peterson, F C]]
[[Category: Peterson FC]]
[[Category: Veldkamp, C T]]
[[Category: Veldkamp CT]]
[[Category: Ccl19]]
[[Category: Ccl21]]
[[Category: Ccr7]]
[[Category: Chemokine]]
[[Category: Chemokine receptor]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/2mp1"