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==Structural Investigation of hnRNP L==
==Structural Investigation of hnRNP L==
<StructureSection load='2mqn' size='340' side='right'caption='[[2mqn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mqn' size='340' side='right'caption='[[2mqn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MQN FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MQN FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2mql|2mql]], [[2mqm|2mqm]], [[2mqo|2mqo]], [[2mqp|2mqp]], [[2mqq|2mqq]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mqn OCA], [https://pdbe.org/2mqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mqn RCSB], [https://www.ebi.ac.uk/pdbsum/2mqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mqn ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hnrnpl, Fblim1, hnrnp-L, Hnrpl ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mqn OCA], [https://pdbe.org/2mqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mqn RCSB], [https://www.ebi.ac.uk/pdbsum/2mqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mqn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HNRPL_RAT HNRPL_RAT] Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity).[UniProtKB:P14866]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allain, F]]
[[Category: Rattus norvegicus]]
[[Category: Blatter, M]]
[[Category: Allain F]]
[[Category: Protein]]
[[Category: Blatter M]]
[[Category: Rna binding protein]]
[[Category: Rrm]]
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